ANTIDEPRESSANTLARNING TA’SIR MEXANIZMI VA KLINIK QO‘LLANILISHI.

Depressiya — bugungi kunda dunyo bo’yicha eng keng tarqalgan ruhiy kasalliklardan biri bo’lib, Jahon Sog’liqni Saqlash Tashkiloti ma’lumotlariga ko’ra yuzlab millionlab insonlarga ta’sir qiladi. Ushbu maqolada antidepressant guruhiga kiruvchi dori vositalarining farmakodinamik va farmakokinetik xususiyatlari, ularning markaziy asab tizimidagi neyromediatorlar (serotonin, noradrenalin, dofamin) almashinuviga ta’siri keng yoritilgan. Trisiklik antidepressantlar, MAO ingibitorlari, selektiv serotonin qayta tutilishining ingibitorlari (SSRI), serotonin-noradrenalin qayta tutilishining ingibitorlari (SNRI) va boshqa zamonaviy guruhlarning ta’sir mexanizmlari qiyosiy tahlil qilingan. Shuningdek, ushbu dori vositalarining klinik qo’llanilish sohalari, nojo’ya ta’sirlari, dorilar o’zaro ta’siri va davolashda individual yondashuv masalalari muhokama etilgan. Maqola farmakologiya, psixiatriya yo’nalishi talabalari va amaliyot shifokorlari uchun nazariy va amaliy ahamiyatga ega.

Depression is one of the most common mental illnesses in the world today, affecting hundreds of millions of people according to the World Health Organization. This article extensively discusses the pharmacodynamic and pharmacokinetic properties of antidepressant drugs, their effect on the metabolism of neurotransmitters (serotonin, noradrenaline, dopamine) in the central nervous system. A comparative analysis of the mechanisms of action of tricyclic antidepressants, MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and other modern groups is carried out. The clinical applications of these drugs, side effects, drug interactions and individual approaches to treatment are also discussed. The article is of theoretical and practical importance for students of pharmacology, psychiatry and practicing physicians.